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The EU list of potential endocrine disruptors

The EU strategy for endocrine disruptors includes the task of compiling a candidate list of potential endocrine disruptors. The list prioritises the substances that must be evaluated further for endocrine disrupting effects.The European Commission has prepared a strategy for endocrine disruptors.

The proposals were compared and a collective EU list of over 432 candidate substances established, which are to be studied further for endocrine-disrupting properties. In order to prioritise efforts, the substances have been subdivided into a number of categories:

Category 1: Substances for which endocrine activity have been documented in at least one study of a living organism. These substances are given the highest priority for further studies. Contains 194 substances. This does not necessarily mean that there is final proof that the substance is an endocrine disruptor, but there is more or less comprehensive evidence of endocrine-disrupting effects in live animals. The substance should therefore be prioritised for further evaluation of endocrine disrupting properties.

Category 2: Substances without sufficient evidence of endocrine activity, but with evidence of biological activity relating to endocrine disruption.

Category 3a and 3b: Substances for which there are no indications of endocrine-disrupting properties or which cannot be evaluated due to a lack of data.

The plan is to convert these lists into a dynamic working list, where substances can be added or removed as more evidence of their endocrine-disrupting properties becomes available.

Category 1

CAS nr. Name
12789-03-6 Chlordane
57-74-9 Chlordane, – cis- og trans-
143-50-0 Kepone (Chlordecone)
2385-85-5 Mirex
8001-35-2 Toxaphene (Camphechlor)
50-29-3 DDT (technical) (Clofenotane)
50-29-3 p,p’-DDT
3563-45-9 Tetrachloro-DDT
50471-44-8 Vinclozolin
12427-38-2 Maneb
137-42-8 Metam Natrium
137-26-8 Thiram
12122-67-7 Zineb
58-89-9 Gamma-HCH (Lindane)
330-55-2 Linuron
1912-24-9 Atrazine
34256-82-1 Acetochlor
15972-60-8 Alachlor
100-42-5 Styrene
118-74-1 Hexachlorobenzene ( HCB)
85-68-7 Butylbenzylphthalate ( BBP)
117-81-7 DEHP (Di-(2-ethylhexyl) phthalate)
84-74-2 DBP (Di-n-butylphthalate)
80-05-7 Bisphenol A(4,4’-isopropylidendiphenol)
1336-36-3 PCB
35065-27-1 PCB 153
32774-16-6 PCB 169
2437-79-8 PCB 47
32598-13-3 PCB 77
53469-21-9 PCB Arochlor 1242
12672-29-6 PCB Arochlor 1248
11097-69-1 PCB Arochlor1254
11096-82-5 PCB Arochlor 1260 (clophen A60)
59536-65-1 PBBs = polybromerede biphenyler
(209 congenere)
40321-76-4 1,2,3,7,8 Pentachloro-dibenzodioxin
(1,2,3,7,8-PCDD)
1746-01-6 2,3,7,8-Tetrachloro-dibenzo-p-dioxin
( 2,3,7,8-TCDD)
107555-93-1 1,2,3,7,8-Pentabromo-dibenzofuran
No CAS Tributyltin compounds
688-73-3 Tributyltin hydride
56-35-9 Tributyl Oxide (bis(tributyltin)oxide)
26354-18-7 Stannane, tributylmecrylate
(Stannane, tributylmethacrylate)
No CAS Methoxyacrylate tributyltin copolymer
4342-30-7 Phenol, 2-(tributylstannyl)oxy)carbonyl-
4342-36-3 Stannane, benzoyloxytributyl-
4782-29-0 Stannane, (1,2- phenylenebis (carbonyloxy))bis(tributyl-
36631-23-9 Stannane, tributyl(naphthalenyloxy)-
(Tributyltin naphtalate)
85409-17-2 Stannane, tributyl- , mono(naphthenoyloxy)-
24124-25-2 Stannane, tributyl (1-oxo-9,12-octadecadienyl)oxy)-
3090-35-5 Stannane, tributyl((1-oxo-9-octadecenyl)oxy)-
26239-64-5 Stannane, (1R-(1alpha,4abeta,4b alpha,10a alpha))-
Tributyl(((1,2,3,4,4a,4b,5,6,10,10a-decahydro-7-isopropyl-
1,4a-dimethyl-1-phenanthryl)carbonyl)oxy)-
1983-10-4 Stannane, tributylfluoro-
2155-70-6 Stannane, tributyl ((2-methyl-1-oxo-2-propenyl)oxy)-
No CAS Tributyltincarboxylate
26636-32-8 Tributyltin naphthalate *
No CAS Tributyltinpolyethoxylate
2279-76-7 Tri-n-propyltin chloride (TPrT chloride)
Flere CAS-numre Triphenyltin
900-95-8 Fentin acetate
95-76-1 3,4-Dichloroaniline
108-46-3 Resorcinol
61-82-5 Amitrol (Aminotriazol)
1836-75-5 Nitrofen
140-66-9 4-tert-octylphenol
25154-52-3 Phenol, nonyl-
1461-25-2 Tetrabutyltin (TTBT)
99-99-0 4-Nitrotoluene
63-25-2 Carbaryl
5103-73-1 Cis-Nonachlor
39765-80-5 Trans-Nonachlor
2971-22-4 1,1,1-trichloro-2,2-bis(4-chloro-phenyl)ethane
65148-80-3 3-MeO-o,p’-DDE
43216-70-2 3-OH-o,p’-DDT
65148-81-4 4-MeO-o,p’-DDE
65148-72-3 4-MeO-o,p’-DDT
65148-75-6 5-MeO-o,p’-DDD
65148-82-5 5-MeO-o,p’-DDE
65148-74-5 5-MeO-o,p’-DDT
65148-73-4 5-OH-o,p’-DDT
4329-12-8 m,p’-DDD
65148-83-6 o,p’-DDA-glycinat
(N-[(2-chlorophenyl)4-chlorophenyl)acetyl]glycin)
53-19-0 o,p’-DDD
3424-82-6 o,p’-DDE
14835-94-0 o,p’-DDMU
789-02-6 o,p’-DDT
72-54-8 p,p’-DDD
1022-22-6 p,p’-DDMU
72-55-9 p,p’-DDE
32809-16-8 Procymidon
8018-01-7 Mancozeb
9006-42-2 Metiram(Metiram-complex
319-85-7 Beta-HCH(isomer til gamma-HCH = Lindan)
608-73-1 Hexachlorocyclo-hexane= HCH mixed (inkluderer gamma-HCH = Lindan)
1689-83-4 Ioxynil
2971-36-0 1,1,1-trichloro-2,2-bis(4-Hydroxyphenyl)ethane(HPTE)
30668-06-5 1,3-Dichloro-2,2-bis(4-methoxy-3- methylphenyl)propane
2971-36-0 Bis-OH-Methoxychlor(1,1,1- trichloro-2,2-bis(4-hydroxyphenyl)ethane (HTPE))
72-43-5 Methoxychlor
72-43-5 p,p’-Methoxychlor
122-14-5 Fenitrothion
82657-04-3 Bifenthrin (@Talstar)
91465-08-6 Cyhalothrin, lambda-
52918-63-5 Deltamethrin
10453-86-8 Resmethrin
60168-88-9 Fenarimol
1918-02-1 Picloram
65277-42-1 Ketoconazol
1087-64-9 Metribuzin
86-50-0 Terbutryn
106-93-4 Ethylene Dibromid (1,2-dibromethan or EDB)
12002-48-1 Trichlorobenzene
608-93-5 Pentachlorobenzene
87-86-5 Pentachlorophenol (PCP)
1806-26-4 4-octylphenol
11081-15-5 4-isooctylphenol
9016-45-9 Nonylphenolethoxylat
85535-85-9 Intermediate chain chlorinated paraffins
85535-84-8 Short chain chlorinated paraffins
84-61-7 Dicyclohexyl phthalate (DCHP)
84-66-2 Diethyl phthalate (DEP)
101-53-1 Phenyl-4-hydroxy-phenylmethane
(4-Benzylphenol eller p-Benzylphenol)
25036-25-3 2,2′-bis(2-(2,3-epoxypropoxy) phenyl)propane
(2,2-BPPP) (isomer til BADGE)
106-89-8 Epichlorohydrin (3-Chloro-1,2-epoxypropane)
35693-92-6 2,4-6-Trichlorobiphenyl
53555-66-1 3,4′,5-Trichlorobiphenyl
67651-37-0 3-Hydroxy-2′,3′,4′,5′- tetrachlorobiphenyl
100702-98-5 4,4′-Dihydroxy-2,3,5,6-tetrachlorobiphenyl
13049-13-3 4,4′-Dihydroxy-3,3′,5,5′-tetrachlorobiphenyl
67651-34-7 4-Hydroxy-2′,3′,4′,5′-tetrachlorobiphenyl
14962-28-8 4-Hydroxy-2′,4′,6′-trichlorobiphenyl
53905-33-2 4-Hydroxy-2,2’, 5′-trichlorobiphenyl
111810-41-4 4-Hydroxy-3,3′,4′,5′-tetrachlorobiphenyl
4400-06-0 4-Hydroxy-3,4’, 5-trichlorobiphenyl
37680-73-2 4-OH-2,2′,4′,5,5′-pentachlorobiphenyl
54991-93-4 Clophen A30
8068-44-8 Clophen A50
No CAS Blanding af 2,3,4,5-Tetrachlorobiphenyl (PCB 61), 2,2’, 4,5,5′-Octachlorobiphenyl (PCB 101) og 2,2′,3,3′,4,4′,5,5′-Octachlorobiphenyl (PCB 194)
56558-16-8 PCB 104(2,2′,4,6,6′-Penta-chlorobiphenyl)
74472-37-0 PCB 114 (2,3,4,4′,5-Penta-chlorobiphenyl)
76842-07-4 PCB 122 (2,3,3′,4,5-Penta-chlorobiphenyl)
57465-28-8 PCB 126(3,3′,4,4′,5-Penta-chlorobiphenyl)
38380-07-3 PCB 128(2,2′,3,3′,4,4′-Hexachloro-biphenyl)
37680-65-2 PCB 18 (2,2′,5-Tri-chlorobiphenyl)
55702-46-0 PCB 21 (2,3,4-Trichloro-biphenyl)
No CAS PCB Aroclor 1016
32598-14-4 PCB 105 (2,3,3′,4,4′ -Penta-chlorobiphenyl)
7012-37-5 PCB 28 (2,4,4′-Tri-chlorobiphenyl)
35693-99-3 PCB 52 (2,2′;5,5′-Tetra-chlorobiphenyl)
35065-28-2 PCB 138(2,2′,3,4,4′,5′- Hexachlorobiphenyl)
35065-29-3 PCB180(2,2′,3,4,4′,5,5′- Heptachlorobiphenyl)
31508-00-6 PCB 118(2,3′,4,4′,5-Penta-chlorobiphenyl)
12642-23-8 PCT Aroclor 5442
56614-97-2 3,9-Dihydroxy-benz(a)anthracene (3,9-DBA)
7099-43-6 5,6-Cyclopento-1,2-benzanthracene
(3,5-CPBA)
56-49-5 3-Methylcholanthrene (3-MC)
57-97-6 7,12-Dimethyl-1,2-benz(a)anthracene
(DMBA)
50-32-8 Benzo[a]pyrene (BAP)
50585-41-6 2,3,7,8-TeBDD
(tetrabrominated dibenzodioxin)
118174-38-2 6-Methyl-1,3,8-trichloro-dibenzofuran
94-82-6 2,4-dichlorophenoxy-butyric acid ( 2,4-DB)
72-33-3 Mestranol
10043-35-3 Boric Acid
104-40-5 Nonylphenol (4-NP)
1113-02-6 Omethoate
1131-60-8 4-Cyclohexylphenol
120-47-8 Ethyl 4-hydroxybenzoate (Ethylparaben)
131-18-0 Di-n-pentylphthalate (DPP)
131-55-5 Benzophenone-2
( 2,2’,4,4’ tetra-hydroxybenzophenon)
131-56-6 2,4-Dihydroxybenzophenon
(Benzophenone-1)
131-70-4 Mono-n-butylphthalate
13593-03-8 Quinalphos (Chinalphos)
15087-24-8 3-Benzylidene camphor (3-BC)
1582-09-8 Trifluralin
1634-04-4 Methyl-tert-butylether (MTBE)
25013-16-5 tert. Butylhydroxyanisol (BHA)
27193-28-8 Phenol, (1,1,3,3-tetramethylbutyl)-
(Octylphenol)
33204-76-1 2,6-cis-Diphenylhexamethyl-cyclotetrasiloxane
36861-47-9 3-(4-methyl-benzylidene)camphor
4376-20-9 Mono-2-ethylhexylphthalate (MEHP)
50-18-0 Cyclophosphamide
611-99-4 4,4’-Dihydroxy-benzophenone
6164-98-3 Chlordimeform
7400-08-0 p-Coumaric acid (PCA)
77-09-8 3,3’Bis(4-hydroxyphenyl) phthalid
(Phenolphthaleine)
77-40-7 2,2-Bis(4-hydroxy-phenyl)-n-butan
(Bisphenol B)
92-69-3 4-Hydroxybiphenyl (4-Phenylphenol)
92-88-6 4,4’Dihydroxy-biphenyl
94-13-3 n-Propyl p-hydroxybenzoate (Propylparaben)
94-26-8 n-Butyl p-hydroxybenzoate (Butylparaben)
96-12-8 Dibromochloropropane (DBCP)
96-45-7 Ethylene Thiourea (ETU)
99-76-3 Methyl p-hydroxybenzoate (Methylparaben)
99-96-7 p-Hydroxybenzoic acid
____________
* The original report to the EU contained this CAS number, which the Danish Environmental Protection Agency has noted is erroneous. Tributyltin naphthalate is already listed under CAS no. 36631-23-9.
Category 1